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The most important issue is the lack of in vivo data validating the importance of the M4 box for H2A eviction and H2A.Z exchange.
Serious deviations are found in high speed condition by making a comparison between the quasi-static and tribo-dynamic simulation results, validating the importance of tribo-dynamic model.
In the present study, we demonstrated that deacetylation of TFEB by SIRT1 facilitates lysosomal biogenesis, which suggests a novel mechanism regulating intracellular degradative pathways and validating the importance of protein acetylation in these processes.
Luckily more and more people are validating the importance of down time.
For six siRNA pools targeting BER enzymes, the negative effect of mRNA knockdown was rescued by expression of the corresponding cDNA, validating the importance of the gene in HIV replication.
Nonetheless, there was a strong tendency in the data from the ESPOIR cohort validating the importance of IL2RA for the disease course in RA.
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The AIDS epidemic validated the importance of basic research.
"I can't go that far myself but I certainly am thrilled and pleased because it validates the importance of the project".
The Edelman Trust Barometer, now in it's 13th year, validates the importance of trust as a key indicator for success for business.
"It makes us see how we're admired and validates the importance of our traditions," Mr. Tsamarin had told me, adding that the Achuar now consider the value of their cultural heritage as a useful leverage against oil development.
She also said that LinkedIn's public offering "validated the importance" of the social networking business.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com