Of note, most of these residues with high CRES are located in or near the pore in the 3D homology model of CaMdr1p, thus validating their relevance (Figure 6).
A second might include explicit partnerships with health workers in the field as a means of validating the relevance of competencies and ensuring key domains are not neglected.
Hence, validating the relevance of these in the context of Asian Indian population will require controlled studies in a cohort representative of the Indian subcontinent.
Figures 1A to 1C show that our experimental conditions stimulated expression of genes known to be induced by hypoxia (namely, VEGF (P <0.05), Sirt1 (P <0.05) and TGF-β1 P <0.05)), thus validating their relevance to hypoxia.
We observed induction of differentiation by ROCKi in cells of mouse, rat, and human origin, of differing derivation and stage of maturation, thus validating the relevance of the observations across species.
The proteases HtrA2/Omi and UCH-L1 represent two key components of TNF-induced necroptosis, validating the relevance of proteolysis not only for apoptosis, but also for caspase-independent PCD.
Clearly, screening methodologies, which can permit enumeration of multiple markers at the same time, offer the best means to discover and then validate the relevance of biomarkers in clinically relevant settings.
Analyses validated the relevance of a five-grade model for DM1 classification.
The obtained results clearly validate the relevance of the proposed algebraic closure.
We validate the relevance of the CASU framework through empirical investigations involving a large set of process models from practice.
This study shows the evolution of the scientific and technological environments of the laser cladding technology and can help public or private organizations to generate new ideas, gain awareness of emerging trends and validate the relevance of projects.
