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We have also provided some numerical experiments to validate that our method is effective and feasible.
The simulation results validate that our method produces higher probability of sparsity pattern recovery and better approximation recovery compared to two state-of-the-art Lasso methods.
As the first miRNA-oriented family classification method, it validates that automatic method can be greatly helpful to solve the problem and using n-gram features is a satisfactory choice to describe miRNA primary sequences [ 37], which thus avoids the traditional multiple sequence alignment procedure.
The false detection rates are below 0.05% in all cases, which validates that our cross-correlation method is feasible in practice.
We validated that our patterning method produces droplet arrays that conform to CLT by comparing the fraction of target cells in the reservoir to the fraction in the patterned droplet array.
We validated that our analytical method can indeed reliably infer initiation probabilities when we simulate ribosome profiling data for S. cerevisiae genes with known initiation probabilities.
Also we demonstrated participation of immune, inflammatory and cell survival pathways in AMD progression that directly validates our method of interactome analysis.
It also validates that our comprehensive and adaptive local scanning method can shorten the scanning time in order of hundreds of times in comparison with the traditional raster scanning without losing any important information about the scanned object.
This comparison validates our method and reveals that the Bacteroidetes profile of French obese patients is similar to that of American obese patients.
Gene ontology (GO) terms are enriched for oogenesis and related processes such as embryonic development, cell cycle regulation, and reproduction that further validate our method of identifying germline-specific genes.
This successful prediction not only validates our method, but also establishes that the method can be applied to predict the miRNAs in any other plant species.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com