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Perhaps illustrating the perils of the needle-in-a-haystack approach, the only two genomic signatures for cancer that have been validated, used in the tests Oncotype DX and MammaPrint, were discovered in a very different ways.
These will be further evaluated and, if validated, used to update the mouse human anatomy mappings.
We therefore chose the EUROPEP-instrument because it is validated, used in many surveys and exists in the languages of all participants [ 27].
For example the "surprise" question is an independent predictor of 1-year mortality [ 33] and is validated used in different clinical settings [ 34, 35].
The CHQ is a generic health status instrument that has been validated, used in a number of populations with chronic illness, including adolescents with CF, and found to be reliable [ 12, 16, 37- 39].
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Classification models will be validated using cross-validation.
The model was internally validated using the validation set.
The final models were validated using the PDB validation server.
The selected model was validated using internal and external validation.
The model was validated using field data.
The design was validated using SystemC.
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