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The biochemical diagnosis of eIF2B-related disorder is difficult as no marker, except the recently described asialotransferrin/transferrin ratio measured in cerebrospinal fluid, has been proposed and validated until now.
However, no reliable molecular marker of sensitivity, resistance, or toxicity to 5-FU has been validated until now[ 10].
Parameters and functional tests appropriate to standardize hepatocyte differentiation and to compare differentiation procedures have been proposed, but are not validated until now.
A decision rule that performed as well as the most rapid diagnostic tests to rule out GAS pharyngitis in children was identified, but has not been validated until now.
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A country-specific tool is now also available for Norway but has not been independently validated in Norway, as nationwide validated hip fracture incidence rates until now have been lacking.
But it should also be considered that no possible biomarker has been validated in large cohort studies until now [ 81].
You validate yourself now through your work.
In a more disturbing twist it came to light that the institutions with which the University of Wales had, up until now been validating programmes, were not warned about the decision from the University of Wales.
Until now, all experimentally validated MADS domain protein tetramers consist exclusively of proteins in the MIKC clade [ 20- 24].
The results of this study allow us, and potentially others, to focus future work to validate more extensively the results obtained until now.
This index has been validated and used in Netherlands, USA and UK until now.
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