To do so, we adapted the clinical composite (which has been validated in trials of chronic HF) to the evaluation of IV levosimendan in a pilot trial of acute decompensated HF (REVIVE-1).
It has subsequently been validated against trials of IPTc [17], [19].
All stimuli have been validated through trials with healthy controls.
New markers may be best validated in trials of neoadjuvant or adjuvant therapies and in advanced disease, where clinical data and outcomes are robust and statistically significant.
However, when validating on trials 1 and 2, trial 3 was included in the full training population, which resulted in some relatedness between training and validation populations.
When validating on trials 1 and 2, trial 3 was included in the training population, which resulted in some of the animals in the validation population to be related to animals in the training population.
The model, which is designed to simulate exposures of people as they move through a changing air pollution field, was developed, validated, and trialed in Northampton, UK.
Until now, tests for diagnosing TB have usually been validated by trialling them on a population of animals 'known' to be either infected or uninfected (e.g., [14], [15], [16]).
For the full training populations, trials 1 through 3 were included when validating on trials 4 through 8.
Underlying this approach is the assumption that diversity indices or population densities are the proper parameters for validating ecotoxicological trials that studied intragenerational effects of individual insects.
A prospective validating trial is currently ongoing.
