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This also represents a substantial challenge to correlate validated toxicity end points including induced gene expression.
Assessment of new normal-tissue sparing technologies such as IMRT and helical tomotherapy require validated toxicity and HRQoL instruments to assess potential improvements.
Thus, validated toxicity tests are highly desirable.
During this procedure, the lowest toxicity measure within a taxonomic group and endpoint (e.g., algal growth inhibition or toxicity to aquatic invertebrates) is selected by the regulatory authorities involved in the review process based on all available validated toxicity data.
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To validate the toxicity issue of the 99mTc-Ch-DTPA, the present results, the histology has been obtained at different regions of the GI tract and there are no significant changes in all portions at different times of exposure.
Validated and accepted alternative toxicity tests will be incorporated into toxicity testing recommendations for regulatory agencies.
A protocol based on the differentiation of hPSCs has been established and validated for use in toxicity testing [ 55].
The FACS-based EST (called "Molecular FACS-EST") was successfully validated for assessing developmental toxicity (Buesen et al. 2009).
There are techniques initially used in explorative studies that were later validated and included into toxicity testing guidelines.
These differences among BAF11 derivatives in inhibition of toxicity further validated our structure-based approach and provided guidelines for the refinement of Aβ pharmacophore.
Most of the studies validated HSPs as biomarker of toxicity on the basis of 2 5 toxicants and even some on the basis of only a single toxicant [ 58, 59, 78].
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