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However, more-recent reports have validated the implication of pachytene piRNAs in the regulation of mRNAs involved in spermatogenesis during spermatocyte and spermatid stages (Goh et al., 2015, Gou et al., 2014, Watanabe et al., 2015, Zhang et al., 2015).
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We are currently trying to validate the implication of the QCK5e06 locus in the genetic architecture of maize flowering time.
Many clinical investigations have clearly validated the prognostic implications of a normal versus an abnormal SPECT MPI [ 25– 27].
As an application of the CA cool storage simulation model developed and validated earlier, the implications of different product loading strategies (batch-wise and step-wise) on the product quality, mechanical plants performance and design aspects were investigated by considering a hypothetical CA cool storage facility.
To further validate the biological implication of this scoring method, we compared the cellular microarray results of serially diluted CD4 T cell lines with IFNgamma production in a parallel control experiment, in which the same numbers of T cells were seeded into a 96-well plate coated with peptide:MHC and anti-CD28/CD11a anti-CD28/CD11ariod ofortheulation (Figure 3).
To validate the direct implication of survivin in Notch2-mediated apoptotic functions, we transfected ECs with survivin, XIAP (a close member of the survivin IAP family) or Bcl2 cDNA before N2ICD overexpression.
Further studies in independent cohorts are needed to validate the clinical implication of the proposed scoring system.
In our study population, individual variations in combination therapy were not controlled; thus, additional clinical studies with a larger number of patients divided into subgroups is needed to validate the clinical implications of elevated IL-34 in the pathogenesis of RA.
To validate the causal implications of association outcomes we selected several putative targets of MYB and measured their expression responses with and without the treatment with an MYB siRNA.
Animal studies further validated the potential therapeutic implications of such observations.
The AIDS epidemic validated the importance of basic research.
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