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Among them, Bcl2, Ccna2, Irs2, Nr4a2 are transcriptionally regulated by CREB1, which is a validated target of miR-296-3p miR-296-3p miR-296-3pe validated targets of miR-298-5p [ 22] 24].
Topoisomerase II is critical for DNA replication, transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophyllotoxins.
This is important as it has been recently identified that reduction in PTEN expression could be a compensatory mechanism to prevent muscle protein degradation [63] and mir-21 is a validated target of PTEN [64].
An experimentally validated target of ZNF24 is VEGFA[ 10].
It is a validated target of miR-661 breast cancer cells (Vetter et al., 2010).
Moreover, STAT3 3′-UTR is a validated target of miR-125b in vitro and in a mouse granulocytic cell line.
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Finally, cDNA sequencing of 26 validated targets of miR-17-92 miR-17-92 miR-17-92functionsuggestsRNAs in conserved, which together with the now publicly available sequence infunctions sets the stage for developing novel RNAi tools for CHO cell engineering.
Although these dietaries, the sources of urolithins, are employed in folk medicine as cognitive enhancer in the treatment of Alzheimer's Disease, urolithins have negligible potential to inhibit acetylcholinesterase and butyrylcholinesterase enzymes, the validated targets of Alzheimer's Disease.
TarBase validated targets of deregulated miRNA.
Previously validated targets of miR-155 such as CEBPβ and SOCS1 were also identified.
The Ryanodine receptor 3 (RYR3) and Ras-related protein 23 (RAB23) transcripts are examples of experimentally validated targets of miR-367.
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