Sentence examples for validated suppressor of from inspiring English sources

AP-1 is a validated suppressor of the hTERT promoter in human cells [33].

The retained molecules were validated as suppressors of lysozyme inhibitory proteins using in vitro experiments revealing four active molecules.

GISTIC identified regions of somatic copy number alterations (SCNA) in a pooled analysis of 26 different cancer types, most of which are not associated with previously validated tumour suppressor genes.

To validate the suppressor gene of the dE2f1-dsRNA phenotypes, we tested the capacity of additional alleles of Su z 2 from the Bloomington stock center (Su (z 2, Su z 2 1.a1, Su z 2 1.b7, Su z 2 1.b8, Su z 2 4d1, Su (z 2 k06344) to modify the dE2F1-RNAi phenotypes (mutant alleles of CG33798 are unavailable).

Recently, the results of a forward genetic screen for tumor suppressors in mice independently validated the role of a number of genes in intestinal tumorigenesis [ 30].

Mutations in five driver genes were described as potential prognostic markers [11 18], but only nonsynonymous mutations in the BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1) (HR: 1.94; p = 0.022) and tumour protein 53 (TP53) (HR: 5.09; p < 0.001) tumour suppressor genes were validated as predictors of poor CSS (Fig. 1 and Table 3).

A mouse knockout experiment has validated the tumor suppressor role in carcinogenesis.

We employed a classic approach that has been used to validate tumor suppressors in the past [ 54].

Taken together, these data validate the importance of NR2F6 as T cell-intrinsic suppressor of T cell-mediated tumor growth control in vivo.

And 50%percentt validated the candidacy of Hillary Clinton.

The suppressors, validated in the W303 genetic background (Thomas and Rothstein, 1989), were also able to rescue the rad53-K227A mutation.