This surrogate marker for efficacy has never been validated in suitably sized studies, and the optimal levels for critically ill patients are not known.
The effect of subcutaneous (sc) enoxaparin on the coagulation cascade is thought to be reflected by anti-factor Xa (anti-Xa) levels [ 7], however, this surrogate marker for efficacy has never been validated in suitably sized studies.
It is therefore necessary that crop models are suitably validated.
Such a novel approach, once developed and suitably validated, could offer more realistic and robust structural fire safety design.
This model, developed by the authors, was based on a RANS, four equations, transition turbulence model and it was calibrated and validated on a suitably designed micro rotor.
Since a reliable upscale criterion has not been developed yet, model predictions have been more suitably validated using real field data, reported in literature.
The method has been suitably validated: the regression equation was calculated from standards prepared in extracts from lyophilized M. aeruginosa PCC7820 (r2≥0.9999) and the linear range covered is from 5 to 500 μg CYN/L, equivalent to 0.18 18.00 μg CYN/g dry weight lyophilized cells.
In contrast, suitably validated computational models can predict all of these parameters, and they are therefore a powerful tool for understanding the musculoskeletal system [4, 5] and are in use in diverse applications from impact biomechanics [6, 7] to rehabilitation engineering [8, 9], surgical simulation [10, 11], and soft tissue drug transport [12].
If suitably validated, this observation may shed new light on possible functional specificities of the different Y lineages.
As an alternative to empirical data, dose-response functions can also be specified using suitably validated simulation models, such as fishery models, crop yield models, and biological growth models.
Initial studies of investigational therapies using tumour-bearing animals should aim to determine whether the target, or an appropriate downstream pathway or phenotype, is modulated by using suitably validated pharmacodynamic biomarkers (Collins and Workman, 2006).
