Moreover, an up-stream activator of complement pathway, ficolin-3, was observed over-represented in the serum of type 2 diabetic patients, which was further validated with statistic significance (p = 0.012) with more clinical samples.
The clinical model improved the prediction, compared with the basic model (cross validated c statistic improved from 0.77 to 0.79; table 2).
The clinical model improved the prediction, compared with the basic model (cross validated c statistic improvement from 0.77 to 0.79, net reclassification improvement 35%); the coronary calcium score in the extended model was a major predictor (0.79 to 0.88, 102%).
Next, we aimed to validate the statistic for polygenic traits.
The discrepancy in the accelerated rate of change and the outdated change management practices still employed today unarguably have much to do with the 70% failure rate of change initiatives — a dismal statistic validated by study after study.
We validated the C statistic by a similar bootstrap procedure using re-sampled data, using 150 iterations (Harrell, 2010).
However, in this particular case, T MVDR outperforms T GL since the χ 2 degrees of freedom is fixed to 2. The theoretical PDF for the MVDR test statistic was validated by MC simulations, as shown in Figure 4. Figure 4 T MVDR (X) test statistic histograms and theoretical PDFs for 4,000 realizations and CN0=34 dB-Hz without interferences.
The effectiveness of the improved statistic is validated by a nonstationary and nonlinear numerical case.
We calculated the c statistic and validated the model according to the steps in the box (the web appendix provides more detail).
The model's predicted probabilities were validated with the c statistic (corresponding to the area under the model's curve) [ 19].
The model's predicted probabilities were validated with the c statistic (corresponding to the model's area under the curve (AUC)) [ 21].
