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The results obtained with the initial group of 48 patients was validated retrospectively in a second cohort of 200 newly diagnosed ALL patients.
We developed rules to guide frequency of CD4 cell count monitoring in HIV infection before starting antiretroviral therapy, which we validated retrospectively in patients from the Swiss HIV Cohort Study.
A simple cheap meningococcal sepsis prognostic score based on readily available, rapid, objective laboratory base excess and platelet count was developed and validated retrospectively.
This program was validated retrospectively on families with and without a BRCA1 or BRCA2 mutation (Parmigiani et al, 1998; Berry et al, 2002).
The Archimedes model has been extensively validated, retrospectively against >50 clinical trials (full details of which can be found online 34) and prospectively against 2 trials: the Diabetes Prevention Program DPPP) 40 and the Collaborative Atorvastatin Diabetes Study CARDSS).
The outcome of the analysis was then validated retrospectively, under an institutional review board-approved protocol from Dana Farber/Harvard Cancer Center (protocol no. 12-519), using a separate cohort of patients who were treated with NovoTTF-100A and bevacizumab at Beth Israel Deaconess Medical Center.
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The binding behavior, as well as the effect on HIV-1 infection, of the resulting peptide (CX4-Mc) was very similar to CX4-M1, validating retrospectively the original design of CX4-M1.
Of course, this score is not intended to substitute for measuring ADAMTS13 activity, which remains mandatory both to confirm the pathophysiology of the TMA and to validate retrospectively initial therapeutic management.
In practice, however, such a definition may prove difficult to validate retrospectively, as one would need to know the intent of each prescribing clinician to decide whether the drugs were prescribed for psychosis per se.
Our previous study completed the preliminary CDSS and validated it retrospectively with the clinical information from outpatients with a confirmed diagnosis of headache [15].
As an illustrative example of a clinical and policy application, the calibrated and validated model retrospectively analyzed the potential benefit of an aspirin chemoprevention program.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com