The previously validated CA125 progression criteria (Rustin et al, 1996b, 2001; Vergote et al, 2000) is defined as either a doubling of the CA 125 levels from the nadir value achieved during previous therapy or a doubling from the upper limit of normal.
In order to validate potential progression markers, real-time quantitative RT PCR analysis on differentially expressed genes was used in cell lines and in fresh frozen primary uveal melanoma specimens.
Based on the CER framework, Songer and her colleagues further developed and validated a learning progression for scientific explanation in the context of elementary biology (Gotwals and Songer 2013; Songer et al. 2009; Songer and Gotwals 2012).
The DAS28 (CRP) has been validated against radiographic progression and physical function.
One of the key model inputs, the hazard equation to predict progression-free survival derived from the bendamustine trial data, 6 was validated against alemtuzumab progression-free survival data as reported in the alemtuzumab trial.
We further selected a panel of 13 CGIs demonstrating increased DNA methylation with disease progression and validated this panel in an independent cohort of 20 benign prostate tissues, 16 PCa, and 8 aggressive CRPCs.
Cell cycle progression was validated by flow cytometry.
Finally, can the importance of cancer-stroma interaction in cancer progression be validated in clinical samples?
Validated measures to monitor progression of SSc are necessary for clinical trials and routine care of patients with SSc.
The microarray results for genes related to cell cycle progression were validated by performing real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) on five upregulated genes.
We focused on miR-144 ZFX axis as a candidate BM regulator of GC progression and validated the origin of the microRNA expression in diverse cell fractions (EpCAM+CD45−, EpCAM−CD45+, and CD14+) by magnetic-activated cell sorting (MACS).
