Our results validate the premise that stereospecific but necessarily weak binding of tropomyosin to F-actin is required for effective thin filament function.
While actual numbers would be hard to validate, the premise is plausible, and worthy of further discussion.
Yes, that's a hangnail for a Silicon Valley VC, but not every company needs to be on a series B to validate its premise.
Overall, the study validates the premise that a convection diffusion based wildfire ignition model captures the anthropogenically-initiated wildfire ignition behavior better than the previously developed gravity model.
But in this instance, what he describes validates the premise of Clinton's candidacy.
The performance of such small-market teams as the Rays, Rangers, Minnesota Twins and Florida Marlins, which are all making the most of limited resources this year, validates the premise of moneyball as a sound one.
There are, however, no reports of the efficacy of HU in the treatment of UM to validate this premise.
A third approach which might be taken to validate the premise would be to carry out studies directed at evaluating APP expression levels in individual neurons to address the presumed pathological consequence of amplification of the APP gene in cortical neurons in AD.
It validated the central premise of Donald Trump's campaign: the donor class of the GOP have been having their way for decades now, and election after election have used the votes of the GOP base to win power and pursue policies that were good for the donor class but have left the average GOP voter in the dust.
Yet they also deemed the effort a success in that it validated the underlying premises of social impact bonds, the financing mechanism behind the program.
Therefore, it is important that the premise be validated in a rigorous manner.
