The short reads overlapping a validated pattern are used in a local greedy assembly, from which we obtain the precise sequence of the TR containing the pattern.
The final output page displays the target sequence ID, targeting miRNA, the predicted interaction pattern and closest experimentally validated pattern along-with the partner miRNA, SVR score and choice to scan for expression analysis based validation across different species.
Furthermore, in many cases several validated patterns are associated with a given mechanism of toxicity.
MetaMap Tox-based pattern ranking using the metabolite changes induced by the high dose captopril treatment matches with validated patterns associated with kidney toxicity, such as glomerular-tubular defect (Supplemental Figure 5).
In many cases validated patterns that have confirmed matches with the metabolite profile of animals treated at one dose (e.g., higher dose) also match the metabolite profile of animals treated at the other dose (e.g., lower dose), but at a lower median correlation value that under expert evaluation cannot be "confirmed" as a match.
According to definition 1.4 this immediately validates pattern (12) but without qualifications this truth definition does not account for pattern (13).
In the age of the universal commentariat we're all White Shoe brigadiers these days, seeking validating patterns of wonder and brilliance in every skill-Vine, every golden run of goal assists, every devastating flat-pitch multicoloured hundred.
To determine and validate patterns of seat belt use and attitudes of taxi drivers on wearing a seat belt following national and provincial seat belt legislation in 2004-2005.
Variation in expression across individuals, such as shown here, cannot be detected in RNA-Seq experiments with pooled individuals, and demonstrates the importance of validating patterns of gene expression in biological replicates.
For historically archived samples, such as ours, Nielsen and Hansen [ 98] recommended including positive and negative controls, having a separate laboratory space and separate chemicals, testing for null alleles with Micro-Checker, using samples with complete documentation of biological information, testing for HWE, and applying more than one statistical test to validate patterns.
Biologs have been used to discover new links in microbial biochemical pathways [ 8], to associate genotypes with phenotypes [ 9, 10], to uncover a decoupling between genotypic and phenotypic diversity across E. coli strains [ 11], and to validate patterns of long-term phenotypic evolution in diverse groups of bacteria [ 12].
