The questionnaire included demographic questions and a battery of validated instruments to assess participation, self-care behavior, knowledge of HF and symptoms of depression.
Strengths include the use of a validated diagnostic interview, a reasonable participation rate, and temporal precedence for the identified risk factors.
By using the IPA software, we further investigated the potential gene targets for the six validated miRNAs and analyzed their participation in the different canonical pathways.
At the initial site visit, once informed consent had been obtained and participant eligibility for participation confirmed, patients were asked by study staff to complete a combination of validated and specially designed PRO questionnaires.
The strengths of the current study are the large sample size, the overall high participation rate, the use of validated headache outcomes and the assessment of the impact of a range of commonly experienced types of interpersonal violence, loneliness, psychological distress, and family cohesion within a population-based cohort of adolescents.
The Bone-specific Physical Activity Questionnaire (BPAQ) is a validated tool for quantifying historical physical activity participation relevant to the musculoskeletal system.
Eligibility for participation was based on the participant's HIV status and being mentally distressed, as determined using a locally validated Self-Reporting-Questionnaire-10 (SRQ-10), a 10 item questionnaire containing two domains, namely depressive symptoms and somatisation.
The strengths of the study include the large and unselected population, the relatively high participation rate, and the use of validated headache diagnoses.
Strengths of the study are the large clinic-based sample from eight headache centres with high participation rates, and the use of validated questionnaires for establishing headache diagnoses and for assessing depression and anxiety.
Moreover, to our knowledge, our study was the first to provide cost-effectiveness data for vaginal self-sampling increasing participation among unscreened women with a validated dry self-sampling device and a PCR-based HPV test.
