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A gene pair fulfilling all above constraints is reported as fusion candidate and will be validated next.
The remaining 4 regions were analyzed by bisulfite sequencing and 2 regions were validated, next to the GZMH (Granzyme H, [MIM 116831]) and TCL1B (T-cell lymphoma/leukemia 1B, [MIM 603769]) genes (Supplementary Table S3).
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Nearly a decade after Next Wave's formation, a report from the Life Sciences Advisory Board of the National Research Council NRCC) now validates Next Wave's longstanding view that the status quo puts the interests of young scientists at risk.
If the connection between high cholesterol and breast cancer is validated, the next step would be to see if lowering cholesterol with statins can reduce the risk of developing cancer".
We designed and validated a next-generation sequencing test panel for ARVC using HaloPlex.
We have developed and validated a next-generation sequencing (NGS) panel that targets all known variants associated with these syndromes.
Promising loci will then be validated using next-generation bisulfite sequencing.
Over 85% of the deletions were validated by next-generation sequence data using read-depth or single-end or paired-end ratio approaches (Table S3).
One tumor harbored a BRAF (D594G) mutation and another with a mutation in NRF2 (G31A), both of which are novel in TSCC, and the mutations have been validated through next-generation target re-sequencing of the same samples (manuscript in preparation).
The genetic alterations that we identified were further validated through next-generation sequencing (NGS) and their association with a specific clinical stage was confirmed by comparison with 36 atypical hyperplasia (i.e. premalignant) tissues.
Such reconstructions also will be essential to validate the next generation of sea ice models.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com