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OR - bioinformatics support, programming, manuscript preparation; IK and AI contributed equally to data validating and manuscript preparation.

Manuscript validated by the boards meeting of SFAR (19/06/2015) and SRLF (06/08/2015).

The manuscript validated by the board meeting of SFAR and SRLF (18/02/2016).

The manuscript validated by the board of the SRLF (12/13/2016) and the SFAR (12/15/2016).

LAS generated the microarray data and reviewed the manuscript, JM validated expression levels of CRYBB2P1 and reviewed the manuscript, KM performed statistical analysis and reviewed the manuscript, CDS provided patient samples and clinical interpretation of the data, REE designed the study and wrote the manuscript.

Both manuscripts validated their methods by comparing with various gene signature algorithms using benchmark microarray data.

The key miRNAs discussed in this manuscript were validated by conducting real-time qRT-PCR for samples from the appropriate stages, including the following: miR-199a and miR-145 at the OP1, OP2, OP3, and OL stages; miR-214 at the OP1 and OP2 stages; miR-184 and miR-1183 athehe GP and OP1 stages (Table 1).

All authors critically reviewed the manuscript and validated the final version.

DAS contributed to the design of the study and drafting of the manuscript and validated the statistical analysis.

However, the two genes added to classifier performance during cross-validation in the training data and the full classifier has subsequently been validated in two additional datasets (manuscript in preparation).

LJL collected and validated data and prepared the manuscript.