In addition, HRQoL was measured using validated assessment tools Limitations relate to the handling of missing data, inherent in this type of analysis Limited data on the health states of patients with progression was available; this is an additional limitation.
That fact that our questionnaire was not extensively pre-tested and validated constitutes another limitation.
14 The Longitudinal Ageing Study Amsterdam Physical Activity Questionnaire (LAPAQ) was developed and validated by keeping these limitations in mind, but it nevertheless has some limitations itself.
These limitation variables have been validated and used previously to assess the limitations associated with several chronic conditions including asthma, diabetes, and rheumatoid arthritis.
To address those limitations, we applied validated algorithms to identify AMI and medical adjustment variables.
24 Despite all known limitations, we have validated the modelling procedure in various western countries with very different smoking patterns.
To compensate for this limitation, results were validated by a group of 30 stakeholders.
The lack of an accepted and validated definition has been a limitation in both genetic and clinical cachexia research.
The fact that the psychiatric illness variable was self-reported and not clinically validated was the most important limitation of the study.
Self-reported family history of CRC was not validated against objective sources, a limitation however that is consistent with other published studies that have used patient record audit [ 18, 23, 28].
