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The fact files were applied to build a comprehensive, validated knowledge base for primary immunodeficiencies (PIDs) called ImmunoDeficiency Resource (IDR) [ 23, 24].
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"What we're doing is crowdsourcing validated knowledge," Forshew tells TechCrunch.
Our work can also be applied towards validating the knowledge base such that the updated model can satisfy all test-cases collected from the domain experts.
This final classification was compared with an expert-based classification to validate both the knowledge base and the Monte Carlo DEA model.
We have determined the validation rate of these approaches for 76 diseases (i.e., in vitro fibroblast mRNA increase); for the Connectivity Map, approximately 5% of tested putative drug gene interactions validated, for causal reasoning engine knowledge base the rate was 10%, and for the targeted drug screen 9%.
In addition, by validating these criteria with the medication knowledge base vendors we were able to arrive on barriers for employing these criteria and provide considerations for how they should be employed in order to improve DDI alerting in EHRs.
IPA also generates gene networks by using experimentally validated direct interactions stored in the Ingenuity Knowledge Base.
Second, we analyze the thrashing problem which is the interminable oscillation of the knowledge base's state when validating by parameter refinement.
The robust process presented here is currently being used to validate GUARDIAN's existing and ever-growing knowledge base containing a number of diseases of interest for public health surveillance.
If there is a concept for that expression, the common sense and inferentialist relations, already existing in the knowledge base, are retrieved to be validated by the user.
These criteria were validated by an expert panel consisting of medication knowledge base vendors, EHR vendors, in-house knowledge base developers from academic medical centers, and both federal and private agencies involved in the regulation of medication use.
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