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It is a simple sequela, a complication of CM, as we affirmed in 2011 [4, 5] and now validated in the recent Global Burden of Diseases 2016 GBD20166) [19].
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Until now, no membrane-bound biomarkers are validated in the clinic, but recent literature shows very promising results in preclinical studies.
Moreover, the detailed kinetic mechanism adopted in the CFD simulations is successfully validated in the conditions of interest using recent literature data [2] on the effect of nitrogen dilution on the flame speeds of several CH4/H2/air lean mixtures.
Furthermore, the organism K. pneumoniae has been extensively validated in the G. mellonella model in recent efforts [ 11, 12].
Numerical models of bare and CFRP strengthened CFST columns were first developed and validated in a recent study of the authors.
This technology was validated in a recent study that compared the Cytocam-IDF device with the SDF technology [ 13].
These findings were largely validated in a recent study, which provided the so far most detailed mathematical model of the Bcl-2 interaction network, including a biologically meaningful quantitative parameterisation of protein amounts and rate constants.
This state-of-the-art approach developed in our group has been applied and validated in various recent studies [34 37].
The prognostic value of estimated Vd/Vt was then validated in two recent prospectively collected ALI/ARDS databases, namely Mayo Clinic [ 20] and ARDS-network [ 21- 23].
The first hypothyroidism-specific instruments have been developed and validated in recent years including the Thyroid-Dependent Quality of Life Questionnaire (ThyDQoL) [ 24, 25].
These results were validated in a recent study, in which miR-21 upregulation resulted in an increase of the anti-apoptosis protein BCL-2 and chemoresistance in breast cancer cells [ 9].
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