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DLQI has been extensively validated in multiple studies [49], [50], [51].
While daily home collection of mucosal samples for herpesvirus culture and PCR has been validated in multiple studies in resource-rich settings, [11], [12], [20], [21], [22], [23], to our knowledge this is the first study to perform intensive mucosal sampling in a resource-limited setting.
With this in mind, we investigated nine signatures that have received great interest and been validated in multiple studies.
The obtained CO and preload and afterload variables have been validated in multiple studies [ 12, 39- 42].
While there are technical discrepancies and different biases of each detection method [ 54,55], miRNA expression signatures have been technically validated in multiple studies.
[F]FMISO is the most widely used and investigated hypoxia marker and has been validated in multiple studies both in humans and animals.
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However, an important feature of these commercially available tests is that they are standardized and validated in multiple independent studies.
The degree of histological differentiation in operable breast carcinomas has long represented one of the best established prognostic factors which have been validated in multiple independent studies [ 2- 4].
The use of our case notes to derive clinically relevant information over long periods of observation, especially for disorders with low prevalence, has been validated in multiple previous studies notably in connection to early onset schizophrenia (e.g. [ 26, 27]).
To our knowledge, no prognostic or predictive biomarkers have yet to be prospectively validated in multiple independent studies to reliably distinguish patients with advanced RCC who are likely to respond from those who will not.
[ 44, 45] However, equivalents of Hofstede's cultural dimensions have been found by several other authors and his cultural dimensions have been validated in multiple other studies [ 20, 32].
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