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It was designed using a validity-driven approach and was validated in diverse samples of individuals in the community [ 18].
The Cardio-vascular reserve index (CVRI) had been empirically validated in diverse morbidities as a quantitative estimate of the reserve assumed by the cardiovascular reserve hypothesis.
PASylation has been successfully applied to numerous biologics, including cytokines, growth factors, antibody fragments, enzymes as well as various peptides, and validated in diverse animal models, from mice to monkeys.
Hence, to enhance treatment efficacy and minimize drug resistance, the HER2-directed CAR approach has been developed and validated in diverse tumor-bearing mouse models, including those of osteosarcoma (Rainusso et al., 2012), breast cancer (Sun et al., 2014), renal cancer (Schonfeld et al., 2015), and glioblastoma (Zhang et al., 2016).
These scoring systems have been prospectively validated in diverse patient populations [ 7- 11].
Items and scales were adapted from colorectal cancer screening intervention trials (9, 10, 11) and have been validated in diverse settings (12, 13, 14, 15, 16, 17).
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The CITAT instrument was further tested and validated in four diverse U.S. hospitals, and demonstrated discriminant validity, convergent validity, reliability, and precision [ 13].
To corroborate recent H. pylori infection (23 ), serum samples from 22 IgG seroconverters and 22 randomly sampled, persistently seronegative adults were tested for H. pylori IgM antibody response in the laboratory of Dr. Perez-Perez by using a mixed strain assay previously validated in ethnically diverse and pediatric populations (9, 24 ).
If this result is validated in other diverse cancer cell types, we propose that STAT3 regulation may be important to cancer development and that it may also be an interesting target for the design of new drug strategies against cancer cells.
Thirty-one SNPs were validated in the 20 diverse Ae. tauschii accessions through conversion into CAPS, dCAPS, and HRM markers.
Intake of key nutrients including; total energy MJ/day), fat(g/day), salt(g/day), sugars (g/day), carotene mg/day), and vitamin C (mg/day) will be assessed using the CADET, which has been validated in an ethnically diverse population[ 13].
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