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In an independent validation set, DKK3 and ITIH5 were further validated in combination with the known biomarker RASSF1A to increase sensitivity of the panel.
A mathematical simulation model was developed, applied and validated in combination with non-linear regression algorithms on bed effluent concentrations to determine the previously-unknown binding properties of stationary phase materials.
Although the hpVIR test is favoured by its ability to be type specific, the self-sampling device Qvintip has been validated in combination with the FDA-approved HC2 method (Stenvall et al, 2007; Sanner et al, 2009).
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A recently developed LC-MS/MS method was validated, both in combination with and without SPE purification, using European Commission Decision 2002/657/EC as a guideline.
Automated imaging systems can be used for higher throughput and detection instruments validated so far in combination with the microwell chip are: Pathway (www.bdbiosciences.com), Cellavista (www.innovatis.com), Odyssey (www.licor.com), Starion (www.scienceimaging.se) and DNA Microarray Scanner (www.agilent.com).
These candidates were validated by qPCR in combination with either the pharmacological Hh/Gli antagonist cyc or the agonist pur in Hh-responsive C3H10T1/2 cells.
The method is exhaustively validated, including experimental design in combination with statistical evaluation (ANOVA) to study the robustness of chromatography and sample preparation.
The results validated that SiLAD technique, in combination with 2-Dimensional Electrophoresis, provided a highly sensitivity method to illustrate the non-disturbed endogenous proteins dynamic changes with a good temporal resolution and high signal/noise ratio.
The conspicuity of this cortical lesion type should be validated on post-mortem slices in combination with histopathology.
These data validate our hypothesis that DFMO, in combination with an oligoamine, not only reduces natural polyamines, but also enhances intracellular levels of the analogue, which may result in greater effectiveness of oligoamines on their targets.
The method was validated with surfactant solutions alone and in combination with Saccharomyces cerevisiae cells.
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