Our results were also validated in an in vivo rat ectopic model with rhBMP-2 loaded hydrogels, which demonstrated superior bone formation with acidic hydrogel as compared to the neutral counterpart.
The system was implemented and further validated in a study of sleep architecture in 7 rats under a 12 12 h LD cycle.
Results In this study, the authors used a previously validated in vivo rat model of VF injury.
Results Using cultured human vocal fold fibroblasts and a previously validated in vivo rat model, the authors show that TGF-β1 and TGF-β3 are differentially expressed and localized to various cell populations within naïve and injured VFM, and in VFM compared with oral mucosa and skin.
We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL), which has potent antiarthritic activity as validated in the rat adjuvant-induced arthritis (AA) model.
Adipotide induces quick and substantial WAT mass regression and improves glucose tolerance that has been validated in mouse, rat, and several non-human primate models.
Maternal obesity-induced developmental programming has been validated in mouse, rat, sheep, and nonhuman primate models and has been shown to affect numerous metabolic pathways culminating in a metabolic syndrome like phenotype [ 20– 23].
The cell lines were transfected with linearised vector DNAs using a standard electroporation protocol previously validated in rat ES cells [2].
The quantitative insulin sensitivity check (QUICKI), a measure of insulin sensitivity that has been validated in both rats and humans (Katz et al. 2000; Cacho et al. 2008), was calculated as 1 / [ log I 0 + log G 0 ], where I 0 is fasting insulin and G 0 is fasting glucose (Solberg Woods et al. 2012).
These laboratory-based methods and the developed colorimetric-based system were then validated in rat transplantation studies of unseeded and seeded tracheal grafts.
