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Nevertheless, it needs to be validated in a large scale population.
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These markers will need to be validated in a larger scale study.
The fault diagnosis tool has been validated in a large-scale office building located in Hong Kong and can effectively find all faults occurring in VAV terminals.
After a threshold is validated in a large-scale study and translated into clinical practice, such a test could drive the administration of antibiotics with few false-positive cases and also could help to schedule catheter changes in cases of infection.
To be a good prognostic marker, NT-pro-BNP should be validated in a large-scale multicenter study.
That was validated in a large-scale consistency study of 1000 E.coli chips using the E.coli RegulonDB, currently the best curated regulatory network, for the investigation of consistency.
Several molecular and gene-expression profiling biomarkers have been proposed as markers of poor prognosis in stage II patients, but none has yet been validated in a large-scale prospective clinical trial (Barrier et al, 2007; Gangadhar and Schilsky, 2010; Ågesen et al, 2012).
These findings should be validated in a large, prospective study.
However, neither has been validated in a large prospective study.
Other tools, such as DeFRA (developed in Italy), have not yet been validated on a large scale.
Methods for new systematic reviews are still in development and remain to be empirically validated on a large scale.
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