The Nef residues M20, E62-65 and P78 are of well-validated importance in the down-regulation of MHC-I in human cells ([14] and references therein).
The importance of validated in vitro assays was stressed, ideally with adoption of common assay methodology across different laboratories.
The results of the analysis not only underscored the importance of validated methods, such as the IPCW analysis, but also unequivocally demonstrated that 5 years of letrozole significantly improved DFS by 15% (HR = 0.85; 95% CI, 0.76 0.96) and OS by 17% (HR = 0.83; 95% CI, 0.7 0.97) [ 51], and reflected the statistics that might have been observed in the absence of selective crossover [ 16].
While qualitative research describing the individual disability experience is highly useful and brings a richer understanding of the problems experienced by patients, this does not diminish the importance of validated self-report scales as a means to describe disability or to report outcomes.
The theoretical and experimental study allowed a validated calculation, which showed the importance of concentrated head losses towards distributed ones.
The finding of the relationship between E2F and docetaxel is interesting biologically and emphasizes the importance of a validated predictor of docetaxel sensitivity in patients with early stage breast cancer.
Report of a WHO (World Health Organization)/IASO (International Association for the Study of Obesity) joint technical meeting recently highlighted the importance of using validated nutrient profiling systems and listed a number of possible validation methods.
The importance of the validated target ALDH4A1 for cell growth is a possible explanation for the known cytotoxicity of ACV in human cells.
The clinical importance of a validated, robust, high content and moderately-high-throughput system to test putative pro-remyelinating compounds is potentially large.
In the absence of validated criteria, and given the importance of considering individual circumstances when making this determination, context specific expert clinical judgment (by AOC and JR) was deemed the most suitable approach.
Development of a validated questionnaire propagated the use and importance of the essential intersecting three-presence framework, consisting of Social, Teaching and Cognitive Presences, that represented all the important activities in an educational experience (Garrison, Anderson, & Archer, 2001, 2010).
