It was not systematically validated for the drug development setting or in clinical trial patients.
The obtained models are validated for the three sites not used in the model development.
Bacterial DNA gyrase is an established and validated target for the development of novel antibacterials.
Thus, RdRPs, like the reverse transcriptase of retroviruses, are validated targets for the development of antiviral therapeutics.
Both enzymes represent validated targets for the development of novel anti-microbial therapies.
The role that microtubules play in mitosis makes them one of the most highly validated targets for the development of chemotherapeutic drugs against rapidly dividing cancer cells [ 5].
S1P receptor models are validated for pharmacophore development including database mining and new ligand discovery and serve as tools for ligand optimization to improve potency and selectivity.
Thus, several new marker genes have shown promise, and large-scale studies are now warranted to clinically validate them for the development of new prognostic tools, diagnostic approaches and biological-targeted therapies (Larson et al, 2009).
Coming on top of a more modest decline in 2002, the development validated for American authorities the $3.2 billion spent here since 2000, mostly for crop eradication.
When imaging biomarkers are validated for use in drug development studies or clinical trials, several additional points should be considered.
