Table 2 compares the model fit in the complete sample with the cross-validated fit in the estimation and validation samples.
The cross-validated fit of the model was medium [ 17] (R:14 %) and the RMSE in out-of-sample prediction comparably high (40 days).
There is a pressing need across neurological and psychiatric disorders for validated, fit-for-purpose biomarkers that can be used as quantitative indicators of disease risk, diagnosis or prognosis that will define homogeneous patient subgroups, predict responses, or monitor drug safety and treatment efficacy.
This validated tool fits on one side of an A4 page and contains items relating to physical (four items: two items on back related disability; one on leg pain and one on co-morbid pain) and psychological predictors (five items: one item each on catastrophising; anxiety; depression; bothersomeness and pain related fear).
The validated kinetic model could fit for both batch and fed-batch fermentation processes as observed from the experimental results.
We used supervised machine learning methods fit to validated, ground truth training data originally predicted using naive methods (see below for details).
Once the final model was found, which included all covariates and validated interactions, it was fit in the full sample using GEE.
Spectroscopic data were fitted using validated software (jMRUI version 2.2, Leuven, Belgium; Naressi et al, 2001).
The logistic regression models were reviewed for goodness-of-fit and validated using the Hosmer-Lemeshow statistic [ 21].
The predictive capabilities of the metamodels are assessed by comparing cross-validated goodness-of-fit estimates, and benchmark Monte Carlo simulations.
No such data exists for N.F.L. players, in large part because the most validated device, made by Riddell, fits in only a few of its helmet models.
