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Strengths of this study included the large number of patients from multiple sites and use of validated efficacy measures to evaluate response to treatment.
A further three patients were excluded at the blind data review meeting because none of them had validated efficacy evaluation after randomization.
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Patients' self-confidence for communicating with doctors was measured using the validated Perceived Efficacy in Patient-Physician Interactions (PEPPI) scale [ 9].
Self-efficacy was evaluated at recruitment using the validated Self-Efficacy for Managing Chronic Disease 6-Item Questionnaire.
Examples of measures that might qualify as baseline predictors include: an observed level of adherence to a comparable product collected during a study run-in, a validated self-efficacy scale measured at screening, or the recorded number of product insertions attempted by a participant at her enrollment visit.
However, as no validated scales for efficacy for the different behaviours exist, claims as to the relative base level of efficacy for a sample will be problematic, and requiring manipulation avoids these problems by enabling comparison of performance of fear appeals under low and high levels of efficacy.
One of the most significant advances towards personalised care in the field of oncology was the establishment of KRAS gene mutation as a validated biomarker predicting efficacy in epidermal growth factor receptor (EGFR) targeted therapies – such as cetuximab and panitumumab - in the treatment of metastatic colorectal cancer (mCRC) [ 2, 3].
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Innovative diagnostic tools for TB, new and enhanced treatment strategies, and validated markers of treatment efficacy are needed to reduce the burden of TB-HIV epidemic.
As there is a constant need for validated biomarkers of therapeutic efficacy the performance of TRS as non-invasive tool for the dynamic evaluation could be investigated in therapeutic interventions.
In contrast, the present trial utilized standardized radiological and clinical entry criteria and measured efficacy with validated outcome measures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com