Sentence examples for validated downstream from inspiring English sources
We would suggest that it is advisable to also monitor the phosphorylation of at least one validated downstream target for AMPK, such as ACC.
We also observed increased expression of the Wnt5b ligand, as well as DKK1, a recently validated downstream target of Wnt signaling [ 27].
However, in this study we did not find an obvious variation in the expression and activation of LEF-1/TCF, one of the validated downstream transcription factors of Wnt/ β-catenin pathway (data not shown).
Throughout library preparation, cDNA was QC validated for downstream sequencing with the Agilent Bioanalyzer.
This paper reports on new information and the diagnostic accuracy of HARP validated against downstream quality of life measured at 1 and 3 months post HARP assessment.
We validate a downstream pathway mediated through the AMPK Sirt1 axis resulting in deacetylation, and thereby inhibition, of NF-κB and, consequently, of secretion of pro-inflammatory molecules.
Further mouse studies are needed to pinpoint and validate the downstream targets of M2 and to investigate the role of the M3 receptor subtype in myopia development.
Gaps that remain to be addressed include linking specific in-utero exposures to subsequent health outcomes based on established miRNA expression profiles and experimentally validating putative downstream targets of the deregulated miRNAs.
With follow-up experiments, the tumor suppressor PDCD4 was validated as a downstream phosphorylation target of CXCL12 signaling in all CLL patient cells examined (n = 10) and HSP27 was similarly validated in a subset of CLL patients (∼25%).
We developed and validated signatures reflecting downstream effects of enhancer of zeste homolog 2(EZhistonestone deacetylase(HDAC) 1, HDAC4, sirtuin 1 SIRT1), and DNA methyltransferase 2 DNMT2).
Among all MADS TF genes, the role of AGL15 has already been experimentally validated in controlling the downstream targets (LEAFY COTYLEDON2, FUSCA3 and ABA INSENSITIVE3) encoding B3 domain TFs, which are the key regulators of embryogenesis during seed development in Arabidopsis.
