Although peer review is widely considered the cornerstone of validating discovery, and there is little doubt that the researchers themselves are best suited to evaluate the work of their peers, the mood is one of change.
For those who suffer from allergies and mental health issues, it's an important — and potentially validating — discovery.
As part of efforts to validate discovery- and target-based protein quantification using iTRAQ and PQD, Wu and co-workers recently reported a change in expression of certain proteins in WT and kin- S49 cells treated with 8-CPT-cAMP for 4 h.
We validated this discovery with a receptor activation assay in COS-7 cells expressing Sv-TKIR, using a reporter SRE-LUC system designed for RTKs, with each of the rIAG proteins acting as the activation ligand.
Gunther Stent, one of the original thinkers in the field of molecular biology, whose research wrestled with and validated the breakthrough discovery of the structure of DNA, died Thursday near his home in Haverford, Pa.
Given the sparseness of the fossil record, there is no guarantee of unearthing evidence of such species, but, in the cases of legs and eyes, the predictions have been validated by discoveries made over the past decades.
To test the validity of our approach, the results of our scan was applied to previously nominated regions to explore how well this method validated previous discoveries.
Investigators have typically "validated" the discoveries by demonstrating that the sub-types possess distinct clinical characteristics, such as case survival.
Additionally, high dimensionality compromises the ability to validate marker discovery, which requires accurately measuring true and false discovery rates (Ransohoff, 2005).
