Adolescents subsequently found this to be more understandable and further validated the contribution it made to the credibility of the site.
To generalize these observations, we validated the contribution of STAMP2 to cell growth in an additional androgen-responsive PCa cell line, VCaP.
Noise was measured in >2,500 proteins using GFP-tagged yeast strains [ 3] and this validated the contribution of mRNA dynamics to protein noise.
Homology-based structure modeling and the biochemical analysis of laboratory-generated protein variants validated the contribution of the five positively selected sites to functional divergence of OryzaTPS1.
Data from clinical trials indicating that B cell depletion with rituximab is highly therapeutic, and well tolerated, in RA patients have validated the contribution of B cells in the pathogenesis of RA [ 2].
Next, to generalize our findings, we validated the contribution of RARRES3 to lung colonization in patient-derived CN37 cells (Gomis et al, 2006) and in 4T1 mouse-spontaneous ER− metastatic BC cells (Aslakson & Miller, 1992).
We subsequently validated the contribution of increased actomyosin contraction and stress fiber instability to doxorubicin-induced cell detachment and apoptosis using pharmacologic inhibitors, blebbistatin, and cytochalasin D. Blebbistatin is a direct inhibitor of myosin II ATPase activity, and cytochalasin D inhibits actin polymerization.
In order to further validate contribution of apoptosis to the reduction of cell proliferation during CCM+DHA treatment, we used a pan-caspase inhibitor (Z-VAD-FMK) to inhibit initiation of the apoptotic process.
In addition, we validated the contributions of the structured diagnoses/ICD-9 codes and the unstructured clinical notes.
Instead, said Sweeney, REF provided a means of validating the contribution of all research: "It's not about favouring one discipline over another". He presented REF not as a perfect measure of impact, but as a first step.
To further validate the contribution of STAT3 signaling in the anti-melanoma effects of SLE, we established A375 stable cells persistently expressing STAT3C, a constitutively active variant of STAT3.
