Sentence examples for validated compounds from inspiring English sources
Thirty-seven of the 60 validated compounds had known biological activity (for example, inhibitors of protein synthesis and topoisomerase activity, antibiotics and antihelmintics).
The predictions were based on the functional group similarity for the query molecule with the in vitro and in vivo validated compounds present in the database of these two online programs.
Moreover, our ranking methodology was reasonable to reduce false positive identifications because our predicted structures that matched with validated compounds all resulted in high rankings.
The top, validated compounds, i.e. 6-hydroxy-DL-DOPA, Reactive Blue 2 and myricetin, were shown to inhibit AP site cleavage activity of whole cell protein extracts from HEK 293T and HeLa cell lines, and to enhance the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate.
Also tenuazonic acid was detected in 21 samples, with apparently high concentration, although this analyte was not part of the validated compounds.
Furthermore, the anti-leishmanial activity of the newly identified and validated compound was tested in vitro against different Leishmania species.
They sequenced the whole genome of the proband, identified all potential functional variants in genes likely to be related to the disease, and identified and validated compound, heterozygous, causative alleles in SH3TC2 (the SH3 domain and tetratricopeptide repeats 2 gene), involving two mutations, in the proband and the other affected family members.
This assay has several advantages including a homogeneous readout and no washing, and RFA can be used to validate compounds in a gel-based screen to provide a semiquantitative read-out of inhibitor potency.
We have also modified the text to clarify the logic behind pursuing 'precocious' 2° islet assays to validate compound effects on endocrine differentiation.
To validate compound 1 as a NOD IgG ligand, it was resynthesized and purified using HPLC and spotted onto a chemically modified glass slide.
Primary respiratory cell cultures derived from CF patients are considered the gold standard to validate compound efficacy and might help as an ex vivo test to predict the propensity of each individual patient to benefit from the in vivo administration of the candidate drug.
