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These variations of NBO charges between the reactant and TS are validated by changes in the corresponding Mulliken charges (Supplementary Table 2S).
The importance of TRAIL-R levels in determining sensitivity or resistance is validated by changes in the TRAIL-R expression in response to chemotherapy, radiation, or steroids that are associated with increased responsiveness (Gong et al, 2006; Kouhara et al, 2007; Oikonomou et al, 2007).
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Substrates were dried for 24 h at RT. Surface modification was validated by quantifying changes in contact angle using the sessile drop method on a goniometer (First Ten Angstroms FTA1000, V2.1), and by X-ray photoelectron spectroscopy of key samples (see Supplementary Methods).
This long-oligonucleotide microarray was subsequently tested and validated by comparing changes in the global expression profiles between B. bronchiseptica RB50 and its Bvg- phase-locked derivative, RB54.
This long-oligonucleotide microarray was then tested and validated by comparing changes in the global expression profiles between Bordetella bronchiseptica RB50 and its Bvg- phase-locked derivative, RB54.
This long-oligonucleotide microarray was then tested and validated by evaluating changes in the global expression profiles between B. bronchiseptica strain RB50 and its Bvg- phase-locked derivative, RB54.
This shows that reading at Time 1 predicts variance in VIQ change that is likely to be genuine (rather than measurement error) because it is cross-validated by changes in brain structure.
Virtual populations comprising sets of virtual subjects were validated by verifying that changes in PCSK9 in response to atorvastatin and changes in LDLc and PCSK9 in response to multiple administration of RG7652 (as monotherapy and in combination with atorvastatin) quantitatively and statistically matched phase I clinical data.
However, SEBs commonly used in prostate cancer chemoprevention studies, such as prostate-specific antigen, high grade prostatic intraepithelial neoplasia, proliferation, and apoptosis, have not been validated by documenting that changes in the SEBs ultimately translate to decreased prostate cancer risk.
The model is validated by using in-house experimental measurements of a current response profile upon electrical load change.
These changes were validated by PCR in 23 samples, 8 samples from patients included in the splice array and 15 additional samples from the independent set.
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