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Nutritional biomarkers can provide such methods, but there is currently no commonly accepted, validated biomarker of flavan-3-ol intake, which meets the recommendations of the 2010 IOM biomarker report [51].
These include its applicability (97%), its performance in the diagnostic and prognosis of the most frequent types of fibrosis, 4 6 15–37 its association with the ActiTest a validated biomarker of activity, 16 21 and its centralised assessment, using pre-analytical and analytical standardisations with reliability algorithms.
FibroTest (FT) is a validated biomarker of fibrosis.
Patients were investigated utilising simple and cheap blood-based biomarkers followed by transient elastography (a validated biomarker of liver fibrosis).
The mutation in KRAS exon 2 is a validated biomarker of resistance to anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (mCRC).
In the aggregate, these results provide evidence for the first time that breast density, a validated biomarker of breast cancer risk in women [ 19, 20], is a valuable screening tool for chemopreventive studies in preclinical models of breast cancer.
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Toenails are not validated biomarkers of lead exposure.
Analyzing these databases in tandem potentiates the discovery of powerful, independently validated biomarkers of drug response.
Toenails are validated biomarkers of arsenic exposure (Slotnick et al. 2007; Slotnick and Nriagu 2006).
However, these tentative results should be interpreted extremely cautiously, because toenails are not validated biomarkers of environmental manganese exposure.
Future kinetic studies would be useful to establish an improved quantitative relationship between nitrate intake and endogenous exposure levels of NOC as well as to develop validated biomarkers of such exposures to be applied in future epidemiological studies taking susceptible subpopulations into account.
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