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Clearly, ANNs – as prediction tools – require significant expertise to build, have significant shortcomings, and should be developed and validated as rigorously as logistic regression models [ 12].
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Several alternate hypotheses have been proposed to explain sodium retention, but they have not been unambiguously validated, as this would require genetic invalidation of hypothesized target genes.
In order to classify a given SNP as "validated," we required the specific base pair position be called as an identical heterozygote in two independent datasets.
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