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By pairing studies of these nonselective compounds with a synapse in the hippocampus that expresses only mGlu7, we have validated activity of these compounds in a native tissue setting.
We examined the following design features: age, sex, and race matching; control for effects of treatment on expression of the biomarker; inclusion of patients with both early and late disease, or both active and inactive disease; longitudinal or cross-sectional design; and use of validated activity and damage measures.
PetPace has a moderate correlation with the most validated activity monitor that has been used in veterinary medicine.
A subsample of all children wears a validated activity monitor, based on accelerometry (Actigraph GT3X, Pensacola, Florida), during the same week.
We also recorded whether validated activity measures were used, and whether patients with a wide range of disease activity were studied, which would help ensure that tests of associations were adequate.
Using a validated activity assay, the KLKB1 rs4253238 genotype was associated with KLKB1 activity using a fluorescent substrate in 10 randomly chosen homozygote subjects (TT vs. CC) from each of the control, asthma, and COPD populations (Fig. 5 A ). Presence of the major (T) allele was associated with increased KLKB1 activity in the control (P<0.01), asthma (P<0.01), and COPD populations (P<0.001).
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The first way to validate activity trackers in free-living conditions was to assess systematic differences.
"And that's really where we want to go in terms of validating activities that you do in the real world".
The primary outcome is physical activity measured using a validated physical activity questionnaire.
Physical activity was assessed through a validated physical activity questionnaire [37].
Physical activity was assessed by the validated physical activity scale for the elderly (PASE) questionnaire.
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CEO of Professional Science Editing for Scientists @ prosciediting.com