These results validate the specificity of these VHHs for dual-spectrum imaging on tumour tissue sections.
To validate the specificity of interaction, we observed that the interaction between β-TRCP1 and ZNRF3, but not RNF43, was impaired when the substrate recognition domain of β-TRCP was mutated to R474A (Figs. 2C and S1D) (Wang et al., 2015).
We use Kineomics? in three steps of our drug discovery program: We use it to identify protein kinases believed to play a role in disease; to validate those kinases as the elements causing the disease; and to validate the specificity of protein kinase inhibitors ("hits") identified in a high throughput screening program.
Inhibition assays were conducted to validate the specificity of bispecific antibodies.
To validate the specificity of NPGA's effects upon eHsp90, we utilized NPGA in tandem with Hsp90ΔATP.
Together, these data validate the specificity of MG132 at the 1 µM concentration in our experimental conditions.
Mononuclear bone marrow cells from Cib1 deficient mice were used to validate the specificity of the antibody.
It should be noted that we used this approach to validate the specificity of a second Taqman gene expression assay for human Pol β (Hs00160263_m1).
To validate the specificity of c-Fos expression to the exposure, we used cage controls that were not exposed to the "open field + odor" arena, but anesthetized and perfused at the same time and day.
To validate the specificity of the rabbit polyclonal antibody used in these studies (Table 1; Santa Cruz H120 anti-Crx) for recognition of Crx we took a combination of sequence alignment, immunoblotting and immunohistochemistry approaches.
Moreover, to validate the specificity of rtv-dependent effects, we used apv as control based on the fact that this drug did not affect DC differentiation and bacterial endotoxin response.
