Sentence examples for validate the mode from inspiring English sources

It will be important to perform classic medicinal chemical optimization, and establishment of structure-activity relationships in relation to the docking boxes to validate the mode of action of compounds emerging as hits.

To validate the mode of a PA cluster, a junction primer (+, half complementary to 3′ end sequence and half complementary to poly(A) sequence) together with an upstream gene-specific primer were designed by Primer3 (version 0.4.0) and synthesized by IDT.

Although AdoHcy accumulation may be responsible for a number of the effects of inhibitors targeted at S-adenosyl- S-adenosyl-ine hydrolase, the ability of some of these inhibitors to undergo metabolic phosphorylation to nucleotides may account for a part of thydrolaseogical actheities, mabilityt difficult tofvalidate the mode of their action [128].

However, it still approaches either in the FD mode or in the HD mode, which further validates the opportunistic mode selection criterion.

We further validated the distributive mode of TUT by an in vitro uridylation assay with dilution.

In addition to validating the potential mode of magnesium release during reaction turnover, the ADP bound structure also provides a glimpse of possible motions and conformations involved in ADP release.

A comparison with predictions from some selected mixed-mode cohesive laws and experimental data available in the literature is also included to further validate the proposed mixed-mode law.

The crystal structures of the BAZ2A bromodomain in complex with four fragment hits validate the predicted binding modes.

The resultant protein ligand complexes were subjected to molecular dynamics simulations, which further validates the binding modes of the hits.

The separation of ethanol and water using as ethylene glycol is well done to validate the feasibility of this mode.

The present model is validated by mode I experiments; the mode II simulation is verified by similar Z-pin shear tests.