Sentence examples for validate the involvement from inspiring English sources
To validate the involvement of DUSPs in the negative regulatory network involving MK3, we used induction of EGR1 as a read-out for mitogen-induced ERK activity [ 37].
To further validate the involvement of several AI genes with GY during drought stress, selective genotyping was performed using Apo/IR64 F3:5 recombinant inbred lines (RILs).
In order to validate the involvement of these genes in i-Extract induced cancer cell killing, we undertook two-way analyses (i) gene specific shRNA-mediated silencing and (ii) bioinformatics and systems biology directed pathway investigation.
The ability of skeletal muscle to consume lactate oxidatively, and the presence of LDH in the mitochondria have been invoked to validate the involvement of lactate in the tricarboxylic acid (TCA) cycle and the oxidative energy-generating machinery [4] [6].
To further validate the involvement of HSP90 proteins and to confirm the possibility that HSP90β, rather than α isoform, is involved in HIF-1α stabilization mediated by bcl-2 in hypoxia, HIF-1α protein expression was evaluated in bcl-2 overexpressing cells after transfection with shRNA targeting the α (shHSP90α) or the β (shHSP90β) isoforms.
To validate the involvement of MGRN1 in the lysosomal phenotype, both melanocytes were transfected with full length MGRN1 or catalytically inactive RING deleted MGRN1ΔR.
Overexpression of TBC1D20 blocked the transport of exogenous vesicular stomatitis virus G protein from the endoplasmic reticulum, validating the involvement of TBC1D20 in this pathway.
We then validated the involvement of these AI genes using in-silico co-localization analysis and selective genotyping.
Finally we validated the involvement of TGFβ in the modulation of these miRNAs.
Further experiments showed that the miRNA gene cluster identified by DIANA-mirExTra is commonly altered in EOC and possibly other human epithelial tumors, thus validating the involvement of these miRNAs in EOC progression.
These enriched GO data further validated the involvement of the differentially expressed genes in allergen sensitizations in BALB/c mice.
