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To validate the functional role of macrophage CD36, we performed unilateral ischemia reperfusion, followed by contralateral nephrectomy.
We also performed in vitro experiments to further validate the functional consequences of variants positively associated with CHF.
The testing of the system was done in two phases: the first in the laboratory, to validate the functional requirements of the developed devices, the networking solution and the mote's power management; the second on the farm, to asses the functional performance of the devices, such as range, robustness and flexibility.
To validate the functional utility of the NSF45K array, we conducted experiments to identify candidate genes involved in light responses.
However, more work needs to be done to validate the functional relevance of these genes and whether they are dependent on the status of DNA-PKcs.
To categorically validate the functional significance of the various transcription factor binding motifs within the hres gene promoter, ChIP (Chromatin Immuno-precipitation assay) was carried out.
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This analysis may provide novel directions for validating the functional significance of alcohol dependence candidate genes.
This experimental evidence roughly validates the functional enrichment results generated computationally.
Prior to the principal experiments, we validated the functional significance of COMT expression on the 2ME level.
Our results revealed an increase in TNFα mRNA in the brains of Dox-induced mice, validating the functional activity of Tat in these animals (data not shown).
This interpretation is further supported by experiments in which we validated the functional test (i.e. stimulation at 5 Hz) with pharmacology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com