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Likewise, gene expression studies should be conducted to validate the consequences of the splice site variants.
To further validate the consequences of the lack of enzyme activity for alpha-N-acetylglucosaminidase, we performed urinary tests to measure the levels of metabolites for the enzyme (Table 3).
To validate the consequences of gene amplification by array CGH, we performed subsequently real-time quantitative PCR analyses for three potential oncogenes (EPHB3, MASP1, or SST) at 3q27.1 q27.3.
If these findings should be taken into account when discussing considering the use of MSC-based therapies in an autologous setting, functional experiments must be designed to validate the consequences of the defect of patients' MSC described in this in vitro study.
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Further experimental research is needed to validate the consequences derived from these theoretical considerations.
In order to validate the functional consequences of miR-21 expression in relation to MMP activation, we stained sections of organotypic cultures with RECK.
To validate the pathophysiological consequences of the interaction between BRAFV600E and MST1 in vivo, animal experiments using thyroid-specific transgenic BRAFV600E mice (Tg-BRAFV600E mice) and MST1 null mice were designed.
To validate the functional consequences of small molecules binding at these sites we created 12 point mutations, either to alanine (smaller) or to tyrosine (larger) on the surface of the DH domain around the pockets.
This mutation is also a splicing mutation affecting the last exon of the gene; however, it has never been validated and the consequences of the mutation remain unclear.
While Veridical does indeed validate the splicing consequence observed, when we say that it validates the mutation we do only mean that it strongly corroborates the mutation as a causative agent of the splicing consequence.
While the justices today appeared sympathetic to the city's goals, they worried aloud about the consequences of validating the checkpoints.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com