Sentence examples for validate targets from inspiring English sources
For validation work the same experiment was used to validate targets identified by p-TAREF in the rice transcriptome.
Many therapeutic areas that rely on human data to validate targets as animal models are seen as poorly predictive.
In addition to her research interests identifying genetic markers of drug response, her current focus is on the application of genetics and regulatory genomics to select and validate targets for drug discovery and development.
Research laboratories able to identify and validate targets better and faster than competitors will be significantly advantaged, and combinatorial approaches and tools will provide relevant benefits at this stage.
They offer a rich source of high quality hits against diverse target sequences and have been used for three main purposes: firstly, to identify and validate targets in phenotypic screens; secondly, to block protein interactions with nanomolar potency binding affinities; thirdly as a source of more efficient cell penetrating peptides for the delivery of a wide range of biologics.
The project will also search for rare individuals with unusually severe or mild disease who could be studied to validate targets. .
Our approach to validate target receptor interaction incorporated fundamental components of nuclear receptor function including VDR transactivation and co-regulator recruitment.
To experimentally validate targeting of these genes by miR-564, we examined the changes in their expression in MDA-MB-231 and MCF-7 cells upon miR-564 overexpression.
To validate target engagement, blocking and displacement studies with mGluR1 antagonist YM-202074 (20mg/kg; i.v.; 2min before and 30min after tracer injection, respectively) were performed.
Consideration of target gene relative expression levels can also be used to help validate target site predictions, which are prone to false positives.
These data indicated that the analysis worked well to validate target pathways of the agents.
