Sentence examples for validate surrogate from inspiring English sources

A set of statistical requirements, known as Prentice's four criteria, must be met to validate surrogate endpoints [ 11].

The 'learn on the way' design is an excellent opportunity to reduce overtreatment and validate surrogate markers of response.

Another statistical approach to validate surrogate outcomes is using data from multiple RCTs that assess surrogate outcomes and patient-centred outcomes.

Given the pivotal role of surrogate outcomes in drug development, and the observed variability in surrogate acceptability both within and between international agencies, more clarity is needed on the nature and timing of evidence needed to validate surrogate outcomes.

The effort to study and validate surrogate biomarkers is never wasted since it may lead to better characterization of the tumor response, personalization of adjuvant treatment, and the design of new prevention strategies.

Monocytes dysfunction is now evaluated by a clinically validated surrogate marker: mHLA-DR expression [4, 27].

To study interventions in this population, we will require validated surrogate markers.

QUICKI is among the most thoroughly evaluated and validated surrogate indices for insulin sensitivity.

This study is predicated on measures of cardiac structure and function which are validated surrogate outcomes of relevant patient outcomes.

Biomarkers for health effects should be related to specific diseases as intermediary endpoints or validated surrogate endpoints of disease risk.

Meta-analytical approaches have been extensively used for validating surrogate endpoints for therapeutic drugs [ 15], but the number of applications to vaccines remains very limited.