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The changes in MG1 have been observed to validate mode change based operation setting (V_{high}) as (390,text {V}) and (V_{low}) as (370,text {V}) and the bus voltages of MG1 and MG2 along with tie-line current flow are shown in Fig. 6.
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It will be important to perform classic medicinal chemical optimization, and establishment of structure-activity relationships in relation to the docking boxes to validate the mode of action of compounds emerging as hits.
To validate the mode of a PA cluster, a junction primer (+, half complementary to 3′ end sequence and half complementary to poly(A) sequence) together with an upstream gene-specific primer were designed by Primer3 (version 0.4.0) and synthesized by IDT.
Although AdoHcy accumulation may be responsible for a number of the effects of inhibitors targeted at S-adenosyl- S-adenosyl-ine hydrolase, the ability of some of these inhibitors to undergo metabolic phosphorylation to nucleotides may account for a part of thydrolaseogical actheities, mabilityt difficult tofvalidate the mode of their action [128].
A model was developed and validated for mode I fatigue crack growth under variable amplitude loading conditions.
The present model is validated by mode I experiments; the mode II simulation is verified by similar Z-pin shear tests.
The previous peel stopper was validated under mode II dominated conditions, but the novel designs were investigated under mode I dominated crack propagation conditions, which are of higher practical relevance.
ZF/DNA homology submodels are built by superposition in crystallographically validated binding modes.
Combined kinetic and mutational analyses of structurally implicated substrate binding residues validate this binding mode.
Upon identification of resistance-conferring mutations, a compound's effect on the activity of both the mutant and wild-type gene products can be used to directly validate a proposed mode of action.
Likewise, the map depicting the traveling behavioral mode validated well (ρ = 0.99, df = 9, P < 0.001) with 21.8% of validation locations occurring in the lowest four bins and 61.3% in the highest four bins.
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