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In summary, development of novel antimicrobial drugs is a combination of chemical, biological and industrial approaches in order to design the active compound, validate its usefulness and developing it for clinical use (De Clercq 2010).
To validate its usefulness for optogenetic applications, we tested ChrimsonSA in hippocampal neurons (Fig. 6e l).
"This test appears to be promising," he says, but cautions that, "thus far, it's been used as a research tool". The next step, he says, is to apply the test on a larger scale and in the community to validate its usefulness as a screening tool.
Based on a recent study of glycolysis in Saccharomyces cerevisiae, we design and perform a series of simulation studies to investigate the statistical properties of the framework and validate its usefulness and utilization in practice.
The SPST, which is simply a monotonic penetration of a 1.5-inch diameter solid steel block into a typical Hamburg Wheel Track Test (HWTT) HMA specimen, was further compared to Hamburg Wheel Track Test (HWTT) in order to validate its usefulness.
Monte Carlo simulation studies are performed to explore the statistical properties of the model and validate its usefulness in practice.
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An explicit finite element solver is used to quantitatively understand the experimental results, thus validating its usefulness as an engineering design tool.
Our findings confirm the robust CGRP-induced light-aversive phenotype of nestin/hRAMP1 mice, which can be a surrogate of photophobia, and validates its usefulness as a model of migraine and other disorders associated with photophobia.
Once the culture conditions were optimized, the test was applied to 90 strains from nine bacterial species, validating its usefulness for differentiating invasive strains (positive) from those non invasive (negative).
Since this novel tool has still not been extensively tested in the literature, and the supplier does not provide any information about the chemical, we first validated its usefulness in detecting autophagy in TM cells.
Further in vitro and in vivo experiments will be conducted to assess efficiency of the entrapped antibacterial and then validate its potential usefulness in prophylaxis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com