And thirdly it's great to have good peer-reviewed publications, because they validate your contribution to the body of knowledge".
Having the above thoughts in mind, we discuss the details of an evaluation we carried out to validate the contribution of the service to the query construction process.
Integration of copy number and expression has provided a list of candidate dominantly acting driver genes, which can be used to underpin functional analysis that will be necessary to validate their contribution to ovarian tumorigenesis.
To validate the contribution of COX-2 to shear-mediated regulation of histones, T/C-28a2 chondrocytes were transfected, prior to their exposure to high fluid shear, with a siRNA oligonucleotide sequence specific for L-PGDS, which is downstream of COX-2 and responsible for ROS production.
In order to validate the contribution of MEK1/2 kinases in the positive regulation of CIP2A expression, AGS cells were treated with UO126, a more specific and potent MEK1/2 inhibitor than the previously used PD98059, and CIP2A protein expression was studied 48 hours post treatment.
To validate the contribution of Rnd3 farnesylation to 14-3-3 14-3-3 14-3-3we used a farnesyltransferase interactionFTI).
Further investigation is needed to validate the contribution of alantolactone to tumor therapy in vivo.
To validate the contribution of ERBB4 to the prosurvival PI3K-Akt pathway, we used short hairpin RNAs (shRNAs) for stable ERBB4 knockdown (kd).
PTEN specific inhibition by a bisperovanadium compound was applied to validate its contribution to mastic oil-mediated anti-tumor growth effects.
However, standardized definitions and methodologies for the identification of the molecular subtypes and prospective clinical trials to validate the contribution of these intrinsic subtypes in addition to the common clinical pathological parameters are still missing [ 16].
