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However, this kind of complex system is difficult to validate comprehensively.
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Although the capabilities of these solvers to capture shock wave have already been verified by some researchers, these solvers still need to be validated comprehensively as commercial CFD software.
The model has been validated comprehensively with good to excellent agreement in our previous work against all available experimental data including for mixture-fraction and velocity fields in non-reacting cases, and flame lift-off length and ignition delay in reacting cases.
We then obtained an updated ADO index in half of our cohorts to improve its predictive accuracy, which in turn was validated comprehensively in the remaining cohorts using discrimination, calibration and decision curve analysis and a number of sensitivity analyses.
However, for the IHC4+C score to be validated comprehensively to ensure its reliability and reproducibility, it would need to be tested more widely, with assays conducted in several different laboratories (Cuzick et al, 2011).
On account of the complexity involved, uncertainties due to lacking knowledge, and limited availability of data on "new" end points (such as Alzheimer's disease, specific immunotoxic mechanisms or ageing), it is not yet possible to establish hypotheses with sufficient reliability and validate them comprehensively.
The surface reflectance products derived using data acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS), however, have been validated more comprehensively.
We used a multi-construct approach for expressing several characteristic fragments of TatAd, to determine their individual structures and to cross-validate them comprehensively within the architecture of the full-length protein.
Numerous tools have been developed for this, encompassing part or all of the EBM domains, and some have been validated more comprehensively than others [ 2, 3].
The only second person measure with evidence of reliability, internal consistency and validity was the CARE, which showed excellent internal consistency, and was relatively comprehensively validated in terms of both content/face validity and convergent validity [ 16].
A global network of sites where both NPP and GPP are measured and scaled over the local landscape is needed to more comprehensively validate the MODIS NPP and GPP products and to potentially calibrate the MODIS NPP/GPP algorithm parameters.
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